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Apexbio Technology LLC Olanzapine 132539-06-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B22405.1
Olanzapine (CAS 132539-06-1) is a small molecule antagonist with high affinity for serotonin 5-HT2 and dopamine D2 receptors both classified as G protein-coupled receptors (GPCRs) In vitro binding studies demonstrate Olanzapine interacts at nanomolar concentrations with dopaminergic serotonergic 1-adrenergic and muscarinic receptors In vivo Olanzapine antagonizes dopamine and serotonin receptors and exhibits weaker efficacy at -adrenergic and muscarinic sites Administration in animal models increases extracellular dopamine and norepinephrine levels in specific brain regions in a dose-dependent manner Olanzapine is widely utilized in neuropharmacological research to investigate antipsychotic mechanisms
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