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Apexbio Technology LLC Olaparib (AZD2281, Ku-0059436) 763113-22-0 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A41545.1

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Olaparib (AZD2281 Ku-0059436 CAS 763113-22-0) is a selective inhibitor of poly(ADP-ribose) polymerase-1 and -2 (PARP-1/2) By targeting PARP enzymes involved in DNA repair Olaparib specifically inhibits the proliferation of BRCA-deficient tumor cell lines and enhances radiosensitivity in experimental tumor models In xenograft mouse models of non-small cell lung carcinoma (NSCLC) Olaparib has been shown to elevate radiation sensitivity and improve tumor perfusion The compound is widely utilized in studies focused on DNA damage responses tumor radiosensitization and targeted therapy strategies for BRCA-associated cancers

Catalog No. 50-000-62527


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