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Apexbio Technology LLC Olmesartan medoxomil 144689-63-4 200mg
Supplier: Apexbio Technology LLC A4082200
Olmesartan medoxomil (CAS 144689-63-4) is the medoxomil ester prodrug of olmesartan which functions as an orally bioavailable antagonist of the angiotensin II type 1 (AT1) receptor Following gastrointestinal absorption it is rapidly converted to its active metabolite olmesartan resulting in potent AT1 receptor inhibition (IC50 8 nmol/L for olmesartan 33 nmol/L for olmesartan medoxomil) The esterification with medoxomil enhances aqueous solubility Olmesartan medoxomil is widely used in hypertension research enabling evaluation of AT1 receptor blockade on vascular tone blood pressure regulation and renal sodium handling in preclinical and clinical models
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