Apexbio Technology LLC Olmutinib (HM61713, BI 1482694) 1353550-13-6 200mg

Supplier:  Apexbio Technology LLC B7813200

Olmutinib (HM61713 BI 1482694 CAS 1353550-13-6) is an irreversible mutant-selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It covalently binds to a cysteine residue near the EGFR kinase domain particularly targeting mutant forms such as L858R/T790M and exon 19 deletion In cellular assays Olmutinib demonstrated potent inhibition of EGFR signaling in NSCLC cell lines H1975 (L858R/T790M GI50 9 2 nM) and HCC827 (exon 19 deletion GI50 10 nM) while showing low activity against wild-type EGFR cell lines It exhibits prolonged inhibitory effects ( 24 h) on EGFR activity and demonstrates in vivo antitumor efficacy in xenograft models without significant adverse effects Olmutinib serves as a tool for studying third-generation EGFR TKI resistance mechanisms in NSCLC

Catalog No. 50-000-88877