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Enzo Life Sciences Olomoucine (high purity) (25mg). CAS: 101622-51-9
Supplier: Enzo Life Sciences ALX350013M025
Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. Alternative name: 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine. Purity: ≥98%. Solubility: Soluble in DMSO (32mg/ml), 100% ethanol (7mg/ml), or methanol. Long Term Storage: -20°C.
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