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Cayman Chemical OlopatdInhydrochlorIde 50mg
Supplier: Cayman Chemical 1199950 MG
A histamine H1 receptor antagonist (Ki =41 nM); 1,059- and 4,177-fold selective for histamine H1 over H2 and H3 receptors, respectively; inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human TM3 cells (IC50s = 9.5, 19, and 39.9 nM, respectively); inhibits passive cutaneous anaphylaxis in rats (ED50 = 49 UG/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50 = 30 UG/kg)
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