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Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 25 MG
Supplier: Medchemexpress LLC 25MGHY14254
Olprinone Hydrochloride, also known as Loprinone Hydrochloride, is a potent phosphodiesterase (PDE) 3 inhibitor with an IC50 of 0.35 μM. It is utilized in research for heart failure due to its positive inotropic and vasodilative effects, and it also demonstrates anti-inflammatory activity.
- Potent PDE3 inhibitor (IC50 of 0.35 μM)
- Used in research for heart failure
- Exhibits positive inotropic and vasodilative effects
- Demonstrates anti-inflammatory activity
- Modulates inflammation associated with myocardial ischemia-reperfusion injury in rats
- Reduces histological evidence of myocardial injury
- Decreases pro-inflammatory cytokines (TNF-α and IL-1β)
- Reduces adhesion molecules (ICAM-1 and P-Selectin)
- Decreases nitrotyrosine formation and NF-κB expression
- Reduces PAR formation and apoptosis
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