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Medchemexpress LLC OM-153 | 2406278-81-5 | 99.3% | C28H24FN7O2 | 1 ML
Supplier: Medchemexpress LLC HY14526710MM/1ML
OM-153 is a potent, orally active tankyrase inhibitor targeting TNKS1/2 with high specificity. It demonstrates strong inhibitory activity against Wnt/β-catenin signaling, which is crucial for cellular proliferation, and has shown antiproliferative effects in COLO 320DM cells.
- Potently inhibits TNKS1 (IC50: 13 nM) and TNKS2 (IC50: 2 nM).
- Effectively inhibits Wnt/β-catenin signaling (IC50: 0.63 nM).
- Exhibits antiproliferative activity in COLO 320DM cells (GI50: 10 nM).
- Inhibits WNT/β-catenin, YAP, and MYC signaling pathways.
- Reduces WNT/β-catenin signaling and tumor progression in COLO 320DM xenografts.
- Potentiates anti-PD-1 immune checkpoint inhibition in melanoma models.
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