Apexbio Technology LLC Omecamtiv mecarbil 873697-71-3 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A83495.1

Omecamtiv mecarbil is a cardiac-specific myosin activator targeting the S1 domain of cardiac myosin It acts by accelerating the release of phosphate (Pi) from the cardiac myosin S1 domain upon actin binding thus facilitating transition from weak to strong actin-bound conformations This mechanistic action enhances cardiomyocyte contractility independent of calcium transient alterations In preclinical studies omecamtiv mecarbil enhances contraction force in isolated cardiomyocytes at submicromolar concentrations and improves cardiac function in animal models of systolic dysfunction without influencing myocardial oxygen consumption Researchers utilize omecamtiv mecarbil to investigate therapeutic approaches in treating systolic heart failure

Catalog No. 50-000-62112