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Selleck Chemical LLC Rigosertib (ON-01910) 50mg 1225497-78-8
Supplier: Selleck Chemical LLC S136250MG
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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