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Medchemexpress LLC Ononetin | 487-49-0 | 99.5% | 258.27 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY10845110MG

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Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM.

  • Completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2.
  • Blocks pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones.
  • Reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity.
  • Suggests TRPM3 may be a tractable target for inflammatory pain.

Catalog No. 50-003-46973


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