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AdipoGen Opaganib
Supplier: AdipoGen AGCR13749M100
Chemical. CAS 915385-81-8. Formula C23H25ClN2O. MW 380.9. Opaganib is a selective inhibitor of sphingosine kinase 2 SPHK2 Ki = 9.8 μM, a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate S1P. S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-α signaling and other inflammatory cytokine production. By inhibiting the SK2 enzyme, opaganib blocks the synthesis of S1P which regulates fundamental biological processes such as cell proliferation, migration, immune cell trafficking and angiogenesis, and is also involved in immune-modulation and suppression of innate immune responses from T cells. Opaganip has similar potency toward sphingosine kinase SK2 and dihydroceramide desaturase DES1.
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