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AdipoGen Ophiobolin A

Supplier: AdipoGen AGCN20431C100
Chemical. CAS 4611-05-6. Formula C25H36O4. MW 400.6. Isolated from Bipolaris leersia. Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport.
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