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Apexbio Technology LLC Oprozomib (ONX-0912) 935888-69-0 25mg
Supplier: Apexbio Technology LLC A193425
Oprozomib (ONX-0912 CAS 935888-69-0) is an orally bioavailable small-molecule inhibitor of the proteasome structurally related to carfilzomib It targets predominantly the chymotrypsin-like proteolytic activity of the proteasome inducing apoptosis and growth inhibition in multiple myeloma (MM) cell lines including those resistant to bortezomib In preclinical models oprozomib activates pro-apoptotic pathways involving caspases-3 -8 -9 as well as PARP cleavage suppresses angiogenesis and tumor cell migration thereby reducing tumor progression and prolonging survival Its biological activity positions oprozomib as a promising compound for MM research
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