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Cayman Chemical Oregon Green488 100mg
SDP

Supplier:  Cayman Chemical 35372100 MG

Encompass_Preferred

A TNIK inhibitor (IC50 21 nM) selective for TNIK over a panel of 46 kinases but does inhibit FLT3 JAK3 PDGFRa TrkA Cdk2/CycA2 and HGK by 80 at 100 nM inhibits phosphorylation of TCF4 and autophosphorylation of TNIK in cell-based assays at 3 UM inhibits the growth and colony formation of HCT116 cells in two-dimensional growth and soft-agar assays respectively as well as reduces tumor growth in an HCT116 mouse xenograft model reduces tumor growth in PDX mouse models of colon cancer at 50 and 100 mg/kg

Catalog No. 50-291-3584


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