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Bachem Orexin A (human, mouse, rat) Trifluoroacetate
SDP

Supplier:  Bachem 4028262.5000

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Orexin A (human, mouse, rat) Trifluoroacetate, Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2, 205640-90-0, C152H243N47O44S4, Mr 3561.16, 5mg. Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse. Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX1R (IC50 = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. The peptide also corresponds to bovine, canine, ovine, and porcine orexin A.

Catalog No. 50-259-818


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