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Cayman Chemical OrforglIpron 10mg
Supplier: Cayman Chemical 3974110 MG
A nonpeptide GLP-1R agonist; induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 3.05 nM); selective for GLP-1R over the GCGR, GIP receptor, and GLP-2R at 100 nM; ) prevents increases in blood glucose levels in glucose-injected mice expressing human GLP-1R but not in glucose-injected Glp1r-/- mice at 0.1, 1, or 10 mg/kg; decreases blood glucose and serum insulin levels in glucose-injected cynomolgus monkeys at 5.4 mg/kg; reduces mean food intake in cynomolgus monkeys at 0.05 or 0.1 mg/kg per day
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