Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC OSI-420 free base 183321-86-0 50mg
Supplier: Apexbio Technology LLC B149550
OSI-420 free base (CAS 183321-86-0) is an active metabolite of erlotinib (OSI-774) exhibiting inhibitory activity against epidermal growth factor receptor (EGFR) tyrosine kinase Mechanistically OSI-420 inhibits EGFR by binding competitively to the ATP-binding site within the intracellular kinase domain thus preventing receptor autophosphorylation and subsequent signaling Additionally through EGFR inhibition it can trigger apoptosis via mitochondrial disruption including loss of mitochondrial membrane potential and cytochrome c release OSI-420 is utilized in biomedical research for studying EGFR-related signaling pathways and apoptosis mechanisms
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?