Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | C30H41N7O8S2 | 50 MG

Supplier:  Medchemexpress LLC HY7907750MG

Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 nM against EGFRL858R and 1 nM against EGFRL858R/T790M. It is effective in inhibiting EGFR phosphorylation in both sensitizing and T790M resistant EGFR mutant cell lines, demonstrating potent activity at low nanomolar concentrations. The compound also exhibits improved pharmacokinetic properties in rats, reduced hERG affinity, and improved IGF1R margins, showing excellent efficacy in preclinical tumor models.

• Irreversible and mutant selective EGFR inhibitor
• Potently inhibits EGFR phosphorylation in T790M mutant cell lines
• Effective against sensitizing EGFR mutant cells
• Shows improved pharmacokinetic properties and safety margins
• Demonstrates efficacy in tumor-bearing mice
• Soluble in water and DMSO for various applications

Catalog No. 50-004-34913