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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA
Supplier: Genscript Corporation Z0306850
Oncostatin M (OSM) is a multifunctional cytokine and belongs to Interleukin-6 (IL-6) subfamily including IL-11 leukemia inhibitory factor (LIF) ciliary neurotropic factor cardiotrophin-1 and novel neurotropin-1. In vivo OSM is secreted from activated T cells monocytes neutrophils and endothelial cells. OSM is related to LIF and share a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM ReceptorBeta or LIF ReceptorBeta to form a ternary complex. OSM stimulates the growth of different types of cells including megakaryocytes fibroblasts vascular endothelial cells and T cells. On the other hand OSM inhibits the proliferation of several cancer cell lines such as solid tissue tumor cells lung cancer cells melanoma cells and breast cancer cells.
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