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Cayman Chemical Osntnthydrate 10mg
Supplier: Cayman Chemical 3341710 MG
An NK3 receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor); selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively); inhibits neurokinin B-induced contractions and acetylcholine release in isolated guinea pig ileal strips; inhibits ovalbumin-induced increases in BALF neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma; has anxiolytic-like and antidepressant-like activities in gerbils at 5 and 10 mg/kg
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