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Medchemexpress LLC Oss 128167 | 887686-02-4 | 98.6% | 366.32 | C19H14N2O6 | 25 MG
Supplier: Medchemexpress LLC HY10745425MG
OSS_128167 is a research-use small molecule that selectively inhibits sirtuin 6 (SIRT6). It has been characterized in cellular and animal studies and shows activity on histone acetylation, metabolic regulation, antiviral effects against hepatitis B virus, and chemosensitization in cancer models. Supplied as a high-purity solid.
- Selective SIRT6 inhibition (IC50 = 89 μM).
- Lower activity against SIRT1 and SIRT2 (IC50s = 1578 μM and 751 μM).
- Demonstrated anti-HBV activity in vitro and in vivo.
- Increases H3K9 acetylation and GLUT-1 expression in cells.
- Induces chemosensitization in multiple myeloma cell lines.
- High reported purity and supplied as a white to light yellow solid.
- For research use only; not for human or clinical use.
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