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Medchemexpress LLC OT-82 | 1800487-55-1 | 100.0% | 424.47 | 50 MG
Supplier: Medchemexpress LLC HY13624150MG
OT-82 is a potent, selective, and orally active inhibitor of NAMPT. It is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD+ dependent manner. It is a promising antineoplastic agent for the study of hematological malignancies.
- Selectively toxic to cells of hematopoietic origin
- Induces cell death in a NAD+ dependent manner
- Demonstrates tissue-selective (HP vs non-HP) cytotoxicity
- Shows cancer-selective (tumor vs normal) cytotoxicity
- Inhibits recombinant NAMPT activity
- Causes dose-dependent reductions in cellular NAD and ATP concentrations
- Results in activation of caspase-3
- Increases sub-G1 DNA content
- Depolarizes the mitochondrial membrane
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