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Medchemexpress LLC OT-82 | 1800487-55-1 | 99.95% | 424.47 | 10 MG
Supplier: Medchemexpress LLC HY13624110MM/1ML
OT-82 is a potent, selective, and orally active inhibitor of NAMPT. It is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD+ dependent manner. It is a promising antineoplastic agent for the study of hematological malignancies.
- Potent, selective, and orally active NAMPT inhibitor
- Selectively toxic to cells of hematopoietic origin
- Induces cell death in a NAD+ dependent manner
- Promising antineoplastic agent
- Demonstrates tissue-selective cytotoxicity
- Inhibits recombinant NAMPT activity
- Reduces cellular NAD and ATP concentrations
- Activates caspase-3 and increases sub-G1 DNA content
- Depolarizes the mitochondrial membrane
- Increases survival in a SC xenograft model of Burkitt's lymphoma
- Potently inhibits tumor growth in a multiple myeloma mouse model
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