Medchemexpress LLC OT-82 | 1800487-55-1 | 99.95% | 424.47 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY136241

OT-82 is a potent, selective, and orally active inhibitor of NAMPT. It is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD+-dependent manner. OT-82 is a promising antineoplastic agent for the study of hematological malignancies.

• Potent, selective, and orally active NAMPT inhibitor.
• Selectively toxic to cells of hematopoietic origin.
• Induces cell death in a NAD+-dependent manner.
• Demonstrates tissue-selective and cancer-selective cytotoxicity.
• Inhibits recombinant NAMPT activity and reduces cellular NAD and ATP concentrations.
• Activates caspase-3, increases sub-G1 DNA content, and depolarizes mitochondrial membrane.
• Stable for 3 years at -20°C or 2 years at 4°C as powder.
• Stable for 2 years at -80°C or 1 year at -20°C when in solvent.

Catalog No. 50-003-47850