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Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.1% | 534.61 | 100 MG
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Supplier:  Medchemexpress LLC HY109097100MG

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Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for the research of brain ischemic injury.

  • Protects neuronal cells against NMDA-induced cell death.
  • Inhibits Ca2+ influx following activation of NMDA receptors.
  • Suppresses H2O2-induced cell death and reactive oxygen species production.
  • Prevents ischemic neuronal death in an occlusion model of MCA.
  • Attenuates impairment of stroke-induced motor function.

Catalog No. 50-003-44358


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