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Medchemexpress LLC OTS186935 hydrochloride | 99.6% | 522.31 | 10 MG
Supplier: Medchemexpress LLC HY122181B10MG
OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. It demonstrates significant inhibition of tumor growth in mouse xenograft models without detectable toxicity. This product also regulates the production of γ-H2AX in cancer cells. This product is for research use only and is not sold to patients.
- IC50 & Target: 6.49 nM (SUV39H2)
- Inhibits A549 cell growth with an IC50 of 0.67 μM
- Shows growth suppressive effects in human cancer cell line derived xenograft models
- Yielded a tumor growth inhibition of 60.8% without significant body weight loss or toxicity in female BALB/cAJcl-nu/nu mice
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