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Apexbio Technology LLC OTS964 hydrochloride 1338545-07-5 2mg
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Catalog No. 502240159
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OTS964 hydrochloride (CAS 1338545-07-5) is a selective inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) demonstrating an IC50 of 28 nM against its target As a dimethylated derivative of OTS514 OTS964 displays high affinity and selectivity for TOPK a serine/threonine kinase implicated in various human malignancies In vitro OTS964 potently suppresses proliferation of multiple TOPK-positive cancer cell lines (IC50 values ranging from 7 6 to 73 nM) while showing markedly reduced activity in TOPK-negative models In in vivo studies OTS964 administered intravenously to mice bearing LU-99 xenografts resulted in significant tumor growth inhibition without notable toxicity Research applications include studying TOPK-related oncogenic pathways and hematopoietic cell differentiation

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Catalog No. 50-224-0159 Supplier Apexbio Technology LLC Supplier No. A95022
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OTS964 hydrochloride (CAS 1338545-07-5) is a selective inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) demonstrating an IC50 of 28 nM against its target As a dimethylated derivative of OTS514 OTS964 displays high affinity and selectivity for TOPK a serine/threonine kinase implicated in various human malignancies In vitro OTS964 potently suppresses proliferation of multiple TOPK-positive cancer cell lines (IC50 values ranging from 7 6 to 73 nM) while showing markedly reduced activity in TOPK-negative models In in vivo studies OTS964 administered intravenously to mice bearing LU-99 xenografts resulted in significant tumor growth inhibition without notable toxicity Research applications include studying TOPK-related oncogenic pathways and hematopoietic cell differentiation

This item is not returnable. View return policy
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