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Medchemexpress LLC OTSSP167 hydrochloride | 1431698-10-0 | 99.78% | 523.88 | 50 MG
SDP

Catalog No. 5000364265
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OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with an IC50 value of 0.41 nM. For research use only, this product is not sold to patients. It inhibits the growth of various cancer cell lines including lung (A549), breast (T47D, DU4475), prostate (22Rv1), and bladder (HT1197) with IC50 values ranging from 2.3 to 97 nM. OTSSP167 can also abrogate the mitotic checkpoint and disrupt MCC and MCC-APC/C interaction in MCF7 cells.

  • Highly potent and ATP-competitive MELK inhibitor.
  • Exhibits strong in vitro activity with an IC50 of 0.41 nM.
  • Inhibits the growth of multiple cancer cell lines (lung, breast, prostate, bladder).
  • Can abrogate the mitotic checkpoint and disrupt MCC/MCC-APC/C interaction.
  • Causes GFP-MELK localization to the cell cortex in prometaphase cells.
  • Results in tumor growth inhibition in xenograft mouse models.

Catalog No. 50-003-64265 Supplier Medchemexpress LLC Supplier No. 50MGHY15512A
May include imposed supplier surcharges.
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OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with an IC50 value of 0.41 nM. For research use only, this product is not sold to patients. It inhibits the growth of various cancer cell lines including lung (A549), breast (T47D, DU4475), prostate (22Rv1), and bladder (HT1197) with IC50 values ranging from 2.3 to 97 nM. OTSSP167 can also abrogate the mitotic checkpoint and disrupt MCC and MCC-APC/C interaction in MCF7 cells.

  • Highly potent and ATP-competitive MELK inhibitor.
  • Exhibits strong in vitro activity with an IC50 of 0.41 nM.
  • Inhibits the growth of multiple cancer cell lines (lung, breast, prostate, bladder).
  • Can abrogate the mitotic checkpoint and disrupt MCC/MCC-APC/C interaction.
  • Causes GFP-MELK localization to the cell cortex in prometaphase cells.
  • Results in tumor growth inhibition in xenograft mouse models.

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