Thermo Scientific Chemicals Ouabain octahydrate, 96%

Catalog No.	Quantity	Packaging
AC161732500	250 mg	Glass bottle
AC161730010	1 g	Glass bottle
AC161730050	5 g	Glass bottle
AC161730250	25 g	Glass bottle

Catalog No. AC161732500 Supplier Thermo Scientific Chemicals Supplier No. 161732500

Description

Ouabain octahydrate, CAS # 11018-89-6, (synonym: gamma-Strophanthin), is a plant-derived organic compound that inhibits the Na+/K+ ATPase pump present in all animal cell membranes. | CAS: 11018-89-6 | C₂₉H₄₄O₁₂·₈H₂O | 728.78 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Ouabain octahydrate is a water-soluble, light-sensitive powder that is stable at ambient temperatures
• It is a glycoside comprised of rhamnose and ouabagenin, and is derived from the ripe seeds of Strophanthus gratus and the bark of Acokanthera ouabaio

Applications

• Ouabain octahydrate works by binding the Na+/K+ ATPase pump, thus disrupting its function, and leading to an increase in intracellular Na+.
• The inhibitory action of ouabain octahydrate on the Na+/K+ pump in cardiac cells makes it a pharmaceutical cardioactive agent
• Ouabain octahydrate has also been found to induce cytotoxic effects through a steroidal signal transduction pathway, in laboratory preparations

Specifications

Chemical Identifiers

• CAS: 11018-89-6
• Molecular Formula: C₂₉H₄₄O₁₂·₈H₂O
• Molecular Weight (g/mol): 728.78
• MDL Number: MFCD00149240
• InChI Key: TYBARJRCFHUHSN-DMJRSANLSA-N
• Synonym: ouabain octahydrate, strophantine octahydrate, quabain octahydrate, ouabain usp, penta a phenanthren-17-yl-2h-furan-5-one;octahydrate, gamma-strophanthin, 3-1r,3s,5s,8r,9s,10r,11r,13r,14s,17r-1,5,11,14-tetrahydroxy-10-hydroxymethyl-13-methyl-3-2r,3r,4r,5r,6s-3,4,5-trihydroxy-6-methyloxan-2-yl oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1h-cyclo, prestwick_370, acocantherine;g-strophanthin
• PubChem CID: 6364534
• IUPAC Name: 3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one;octahydrate
• SMILES: CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O

• Melting Point: 260.0°C
• Color: White
• Infrared Spectrum: Authentic
• Assay Percent Range: 95% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 250 mg
• Beilstein: 15, V,5, 123
• Merck Index: 14, 6901
• Specific Rotation Condition: − 33.00 (20.00°C c=1,H2O,on dry subs.)
• Specific Rotation: − 33.00
• Solubility Information: (1% in water) Clear colorless
• Formula Weight: 728.78
• Percent Purity: 96%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Ouabain octahydrate

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement Fatal if swallowed. Toxic if inhaled. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing/eye protection/face protection. Get medical attention/advice if you feel unwell. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

SDS

RUO – Research Use Only