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Enzo Life Sciences Oxamflatin (5mg). CAS: 151720-43-3
SDP

Supplier:  Enzo Life Sciences ALX270379M005

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Potent inhibitor of mammalian HDACs (histone deacetylases) (IC50=15.7nM). Acts as a ligand for the enzyme active site metal ion. Upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells. Elevates the expression of extracellular matrix proteins fibronectin and gelsolin. Induces apoptosis in P-glyoprotein (Pgp) positive and Pgp negative multidrug resistant cells. Alternative name: (2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic acid. Formula: C17H14N2O4S. MW: 342.4. Purity: ≥95% (HPLC). Appearance: Tan to yellow solid. Solubility: Soluble in DMSO, methanol or acetonitrile. Long Term Storage: +4°C. Handling: Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.

Catalog No. 50-200-8524


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