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Cayman Chemical OxotremorInsesquIfumarAT 100mg
Supplier: Cayman Chemical 35707100 MG
A muscarinic acetylcholine receptor agonist; binds to M1, M2, M3, and M4 mAChRs (Kis = 3.31, 9.33, 5.24, and 7.08 µM, respectively, for the human receptors); inhibits ACh release in rat cerebral cortical slices at 10 µM, an effect that can be reversed by atropine; induces tremors, salivation, and lacrimation in mice (ED50s = 0.11, 0.22, and 0.28 mg/kg); induces analgesia in the hot plate test in mice at 0.5 mg/kg; has been used to induce parkinsonian symptoms as a model of Parkinson's disease in mice
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