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Cayman Chemical Oxymetazoline (hydrochloride), Purity: ≥95%, CAS: 2315-02-8, 1 g
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Catalog No. 502995149
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An agonist of α1- and α2-ARs (Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR); acts as an agonist of 5-HT1 receptors (Kds = 4.68, 25.7, 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively); increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM); acts as a partial agonist of the α2-AR in perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release); acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine, respectively (Kds = 110 and 257 nM, respectively); inhibits forskolin-stimulated adenylate cyclase activity (EC50s = 18.6, 24.0, and 44.7 nM in tissues expressing high levels of 5-HT1A, 5-HT1B, and 5-HT1D receptors, respectively) and accumulation of inositol phosphates (EC50 = 269 nM in pig choroid plexus preparations, which highly express 5-HT1C receptors); decreases nasal pressure in dogs by 6.9% when used at a dose of 0.2 μg/kg

Catalog No. 50-299-5149 Supplier Cayman Chemical Supplier No. 238261 G
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An agonist of α1- and α2-ARs (Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR); acts as an agonist of 5-HT1 receptors (Kds = 4.68, 25.7, 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively); increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM); acts as a partial agonist of the α2-AR in perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release); acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine, respectively (Kds = 110 and 257 nM, respectively); inhibits forskolin-stimulated adenylate cyclase activity (EC50s = 18.6, 24.0, and 44.7 nM in tissues expressing high levels of 5-HT1A, 5-HT1B, and 5-HT1D receptors, respectively) and accumulation of inositol phosphates (EC50 = 269 nM in pig choroid plexus preparations, which highly express 5-HT1C receptors); decreases nasal pressure in dogs by 6.9% when used at a dose of 0.2 μg/kg

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