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Apexbio Technology LLC P 22077 1247819-59-5 10mg
SDP

Supplier:  Apexbio Technology LLC A819810

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P 22077 (CAS 1247819-59-5) is a small molecule inhibitor targeting ubiquitin-specific protease 7 (USP7 also known as HAUSP) and to a lesser extent deubiquitinase USP4 USP7 modulates the stability of several regulatory proteins including p53 impacting apoptosis pathways in cancer biology P 22077 demonstrates potent USP7 inhibition with IC values of 8 6 nM in singleplex and 7 8 nM in multiplex in vitro assays and shows minimal activity against related enzymes DEN1 and SENP2core Cellular studies suggest that P 22077-mediated USP7 inhibition destabilizes Tip60 attenuating p53-dependent apoptosis The compound is currently utilized in preclinical research investigating the role of deubiquitination in tumorigenesis

Catalog No. 50-000-90326


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