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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.4% | 315.32 | 10 MM * 1 ML
SDP

Catalog No. 5000352479
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P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.

  • Inhibits USP7 and DUB USP47 with EC50s of 8.01 μM and 8.74 μM
  • Inhibits a smaller subset of DUBs at concentrations of 15-45 μM
  • Reduces cell viability of neuroblastoma (NB) cells at 0-20 μM
  • Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells
  • Enhances cytotoxic effect of Doxorubicin and Etoposide on NB cells
  • Shows potent antitumor activities in an xenograft mouse model

Catalog No. 50-003-52479 Supplier Medchemexpress LLC Supplier No. HY1386510MM/1ML
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P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.

  • Inhibits USP7 and DUB USP47 with EC50s of 8.01 μM and 8.74 μM
  • Inhibits a smaller subset of DUBs at concentrations of 15-45 μM
  • Reduces cell viability of neuroblastoma (NB) cells at 0-20 μM
  • Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells
  • Enhances cytotoxic effect of Doxorubicin and Etoposide on NB cells
  • Shows potent antitumor activities in an xenograft mouse model

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