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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.42% | 315.32 | 100 MG
Supplier: Medchemexpress LLC HY13865100MG
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor, also inhibiting USP47. It causes DUBs inhibition in HEK293T cells and significantly reduces the viability of Neuroblastoma (NB) cells. P 22077 increases p53 activity, inducing apoptosis in p53 wild-type and HDM2-expressing NB cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.
- Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
- Also inhibits USP47
- Reduces neuroblastoma cell viability
- Increases p53 activity and induces apoptosis
- Enhances Dox and VP-16 cytotoxic effects
- Demonstrates potent antitumor activities in mouse models
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