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Medchemexpress LLC P-CAB agent 2 | 1978371-23-1 | C22H25FN2O4S | 25 MG
SDP

Catalog No. 5000374764
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P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It effectively inhibits H+/K+-ATPase activity with an IC50 value of less than 100 nM. This agent also demonstrates inhibition of the hERG potassium channel with an IC50 value of 18.69 μM, shows no acute toxicity, and effectively inhibits histamine-induced gastric acid secretion.

  • Inhibits H+/K+-ATPase activity with an IC50 value of <100 nM.
  • Inhibits the hERG potassium channel with an IC50 value of 18.69 μM.
  • Shows no acute toxicity.
  • Inhibits histamine-induced gastric acid secretion.
  • In vitro, it inhibits the hERG potassium channel with an inhibition rate of 86.21% at 100 μM.
  • In vivo, it inhibits histamine-induced gastric acid secretion in SD rats at a dosage of 2 mg/kg with an acid suppression rate of 55.4%.
  • In vivo, it shows no acute toxicity at 600 or 2000 mg/kg in SD rats.

Catalog No. 50-003-74764 Supplier Medchemexpress LLC Supplier No. 25MGHY153219A
May include imposed supplier surcharges.
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P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It effectively inhibits H+/K+-ATPase activity with an IC50 value of less than 100 nM. This agent also demonstrates inhibition of the hERG potassium channel with an IC50 value of 18.69 μM, shows no acute toxicity, and effectively inhibits histamine-induced gastric acid secretion.

  • Inhibits H+/K+-ATPase activity with an IC50 value of <100 nM.
  • Inhibits the hERG potassium channel with an IC50 value of 18.69 μM.
  • Shows no acute toxicity.
  • Inhibits histamine-induced gastric acid secretion.
  • In vitro, it inhibits the hERG potassium channel with an inhibition rate of 86.21% at 100 μM.
  • In vivo, it inhibits histamine-induced gastric acid secretion in SD rats at a dosage of 2 mg/kg with an acid suppression rate of 55.4%.
  • In vivo, it shows no acute toxicity at 600 or 2000 mg/kg in SD rats.

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