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Medchemexpress LLC p,p'-DDE | 72-55-9 | 99.9% | 1 ML
SDP

Catalog No. 5000411210
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p,p'-DDE (4,4'-DDE) is a major and persistent metabolite of DDT. It acts as an orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. This compound can impact the development and function of the male reproductive system, and high serum concentrations may contribute to the risk of type 2 diabetes in women.

  • Inhibits androgen binding to the androgen receptor.
  • Inhibits androgen-induced transcriptional activity.
  • Affects male reproductive system development and function.
  • May be a risk factor for type 2 diabetes in women due to high serum concentrations.
  • Effectively inhibits androgen receptor transcriptional activity at 0.2 μM.
  • In vivo studies show effects on anogenital distance, puberty onset, and reproductive organ weights in male rats.

Catalog No. 50-004-11210 Supplier Medchemexpress LLC Supplier No. HYB198610MM/1ML
May include imposed supplier surcharges.
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p,p'-DDE (4,4'-DDE) is a major and persistent metabolite of DDT. It acts as an orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. This compound can impact the development and function of the male reproductive system, and high serum concentrations may contribute to the risk of type 2 diabetes in women.

  • Inhibits androgen binding to the androgen receptor.
  • Inhibits androgen-induced transcriptional activity.
  • Affects male reproductive system development and function.
  • May be a risk factor for type 2 diabetes in women due to high serum concentrations.
  • Effectively inhibits androgen receptor transcriptional activity at 0.2 μM.
  • In vivo studies show effects on anogenital distance, puberty onset, and reproductive organ weights in male rats.

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