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ABclonal Technology p-PLC gamma 1 PLCG1-Y783
Supplier: ABclonal Technology AP1340100UL
The protein encoded by this gene catalyzes the formation of inositol 1 4 5-trisphosphate and diacylglycerol from phosphatidylinositol 4 5-bisphosphate This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators For example when activated by SRC the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi where it activates Ras Also this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase Two transcript variants encoding different isoforms have been found for this gene
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