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Apexbio Technology LLC P005091 882257-11-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30235.1
P005091 (CAS 882257-11-6) is an inhibitor that selectively targets the ubiquitin-specific protease 7 (USP7) also known as herpes-associated ubiquitin-specific protease (HAUSP) By blocking USP7-mediated deubiquitination P005091 promotes degradation of HDM2 resulting in altered regulation of downstream targets including increased cellular levels of tumor suppressor proteins p53 and p21 Through USP7 inhibition P005091 can downregulate claspin and suppress phosphorylation of DNA checkpoint kinase Chk1 enhancing genotoxic drug sensitivity and inducing apoptosis in cancer cell lines irrespective of p53 mutational status This makes P005091 relevant as a research probe for studying USP7-dependent signaling pathways and cancer cell biology
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