Cayman Chemical P276-00hydrochlorIde 10mg

Supplier:  Cayman Chemical 3984510 MG

A Cdk9, Cdk4, and Cdk1 inhibitor (IC50s = 0.020, 0.063, and 0.079 µM, respectively); selective for these CDKs over Cdk2/cyclin E, Cdk2/cyclin A, Cdk6, and Cdk7 (IC50s = 2.54, 0.224, 0.396, and 2.87 µM, respectively), as well as a panel of eight other kinases; induces apoptosis in HL-60 cells at 1 µM; induces cell cycle arrest at the G1 phase in synchronized H460 cells at 1.5 and 5 µM; reduces tumor volume in a H460 mouse xenograft model at 50 mg/kg once per day; inhibits reactivation of latent HIV-1 induced by prostratin, panobinostat, or JQ-1 in 24ST1NLESG cells (IC50s = 0.1, 0.07, and 0.075 µM, respectively)

Catalog No. 50-294-2168