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Enzo Life Sciences p53 monoclonal antibody (PAb421) (50 µg)
Supplier: Enzo Life Sciences BMLSA2930050
PAb421 antibody induces allosteric changes in certain tumor-derived p53 mutants and restores tumor suppressor activity. Microinjection of PAb421 into SW480 colorectal carcinoma cells restored transcriptional activation function to the resident mutant p53 (Arg to His 273, Pro to Ser 309). The epitope for PAb421 is contained within the "p53 activator peptide" 46. Thus the antibody recognizes this peptide and has been used to examine cellular uptake of the p53 activator peptide. Clone: PAb421. Isotype: IgG2a. Immunogen: Synthetic peptide corresponding to aa 371-380 of human p53. Species reactivity: Human, Mouse, Rat. Applications: ICC, IHC, IP, WB. Purity: Purified. Formulation: Liquid. In phosphate buffer containing 0.02% sodium azide.
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