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Biotium p53 Tumor Suppressor Protein(PAb240), CF640R conjugate, 0.1mg/mL
Supplier: Biotium BNC401634500
The specificity of this monoclonal antibody to its intended target was tested by HuProt™ Array, containing more than 19,000 full-length human proteins. PAb240 binds to the C-terminus (aa213-217) of both wild type and mutated p53 in denatured samples and FFPE sections, but is reported to selectively detect mutant p53 in native samples by immunoprecipitation and ELISA. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased hal
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