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Medchemexpress LLC P62-mediated mitopha 100mg | 1809031-84-2 | 392.15 | C14H9IN4O2 | 100 MG
Supplier: Medchemexpress LLC HY115576100MG
P62-mediated mitophagy inducer (PMI) is a small-molecule activator of p62-mediated mitophagy used as a pharmacological tool to study mitophagy pathways. It activates mitochondrial autophagy without recruiting Parkin or collapsing mitochondrial membrane potential, and it stabilizes Nrf2 and upregulates p62 at active concentrations.
- Activates mitochondrial autophagy independent of Parkin recruitment.
- Remains active in cells lacking a fully functional PINK1/Parkin pathway.
- Stabilizes Nrf2 and upregulates p62 expression at effective concentrations.
- Well characterized by NMR, HRMS, and elemental analysis for research applications.
- Solid compound, soluble in DMSO for stock preparation.
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