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TARGETMOL CHEMICALS INC PA-8 5MG
SDP

Catalog No. 502579966
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Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective effective and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo. purity: 97%

Catalog No. 50-257-9966 Supplier TARGETMOL CHEMICALS INC Supplier No. T410055MG
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Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective effective and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo. purity: 97%

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