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LifeSensors PROTAC Assay Plate Kit
Supplier: LifeSensors PA09500096
PROTACs are heterobifunctional molecules that recruit an E3 ligase to a target protein, leading to its ubiquitination and degradation. They enable degradation of previously undruggable proteins. LifeSensors has developed a rapid, quantitative, high‑throughput plate‑based method to measure PROTAC‑ and E3‑mediated ubiquitination and degradation using endogenous proteins, eliminating the need for engineered cell lines or tagged targets. For in‑vitro evaluation, the PA770 PROTAC Ubiquitination Assay Kit provides a ready‑to‑use solution for Cereblon, VHL, and MDM2, with additional E3 ligases available as custom options. For profiling molecular glues, the MG780 kit offers a parallel in‑vitro ubiquitination assay optimized for glue‑mediated interactions. These tools streamline screening and enable accurate assessment of targeted degradation strategies
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