Thermo Scientific Chemicals Paclitaxel, 99+%

Description

Paclitaxel, also known as Taxol, CAS # 33069-62-4 is a chemotherapeutic drug that acts through stabilizing microtubule assembly and arresting cell cycle progression.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Paclitaxel is a naturally ocurring compound originally isolated from the tree T. brevifolia

Paclitaxel binds tubulin and stabilizes microtubule formation, preventing disassembly

Paclitaxel is used as a drug to arrest cells at the mitotic checkpoint and block cell cycle progression, thus inducing death of cancer cells

Applications

Paclitaxel can be used in preclinical laboratory research on diseases such as cancer, heart disease, inflammatory disorders, and hepatic fibrosis

Paclitaxel can be used as a tool in cell biology to study mitotic checkpoint arrest conditions and downstream signaling cascades

Specifications

Chemical Identifiers

• CAS: 33069-62-4
• Molecular Formula: C47H51NO14
• Molecular Weight (g/mol): 853.92
• MDL Number: MFCD00869953
• InChI Key: RCINICONZNJXQF-VAZQATRQSA-N
• Synonym: paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel
• PubChem CID: 133640187
• IUPAC Name: (1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
• SMILES: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

• Melting Point: 213.0°C to 216.0°C
• Color: White
• Infrared Spectrum: Authentic
• Assay Percent Range: 99% min. (HPLC)
• Quantity: 1 mg
• Merck Index: 15, 7081
• Solubility Information: Solubility in water: sparingly soluble. Other solubilities: soluble in methanol,dmso,acetonitrile
• Formula Weight: 853.9
• Percent Purity: 99+%
• Physical Form: Powder
• Chemical Name or Material: Paclitaxel, 99+%

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement: Causes serious eye damage. Suspected of causing cancer.
Precautionary Statement	GHS P Statement: Wear eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Use personal protective equipment as required. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
RTECSNumber	DA8340700

SDS

RUO – Research Use Only