AdipoGen PAG Cbp pAb IG-452

Supplier:  AdipoGen AG25T0108C100

Polyclonal Antibody. Recognizes mouse, rat and human PAG/Cbp. Source Rabbit. Applications ICC, IP, WB. Liquid. In PBS containing 0.02% sodium azide. PAG is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse bands of 80-90kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR T cell antigen receptor-mediated signaling in T cells and FCER1 high affinity immunoglobulin epsilon receptor-mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition.

Catalog No. 50-256-3165