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Medchemexpress LLC Palacaparib | 2756333-39-6 | 98.3% | C21H22F2N6O2 | 50 MG
SDP

Catalog No. 5000354264
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AZD-9574, also known as Palacaparib, is a potent and brain-penetrant PARP1 inhibitor, exhibiting over 8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. It functions by selectively inhibiting and trapping PARP1 at sites of single-strand breaks (SSBs), making it an effective anti-cancer agent. It is suitable for research in HRD+ breast cancer and advanced solid malignancies.

  • Potent and brain-penetrant PARP1 inhibitor
  • Over 8000-fold selectivity for PARP1
  • Selectively inhibits and traps PARP1 at single-strand breaks (SSBs)
  • Anti-cancer agent for HRD+ breast cancer and advanced solid malignancies research
  • Inhibits PARP1 enzymatic activity with IC50s between 0.3-2 nM
  • Demonstrates sustained tumor growth suppression in intracranial xenograft models

Catalog No. 50-003-54264 Supplier Medchemexpress LLC Supplier No. HY14580450MG
May include imposed supplier surcharges.
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AZD-9574, also known as Palacaparib, is a potent and brain-penetrant PARP1 inhibitor, exhibiting over 8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. It functions by selectively inhibiting and trapping PARP1 at sites of single-strand breaks (SSBs), making it an effective anti-cancer agent. It is suitable for research in HRD+ breast cancer and advanced solid malignancies.

  • Potent and brain-penetrant PARP1 inhibitor
  • Over 8000-fold selectivity for PARP1
  • Selectively inhibits and traps PARP1 at single-strand breaks (SSBs)
  • Anti-cancer agent for HRD+ breast cancer and advanced solid malignancies research
  • Inhibits PARP1 enzymatic activity with IC50s between 0.3-2 nM
  • Demonstrates sustained tumor growth suppression in intracranial xenograft models

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