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Cayman Chemical Pam2CSK4 trifluoroacetate sa
Supplier: Cayman Chemical 33338500 UG
A bacterial lipopeptide and TLR2 agonist; selective for TLR2/TLR6 over TLR2/TLR1 (EC50s = 0.015 and 4.12 ng/ml, respectively, in reporter assays using human receptors); increases levels of iNOS and the production of NO in RAW 264.7 macrophages at 100 ng/ml; stimulates osteoclast formation, induces gingival inflammation, and decreases alveolar bone mass in a mouse model of periodontitis at 5 UG/animal; reduces parasite burden and enhances the response to antigen in a mouse model of lymphatic filariasis induced by B. malayi when used as an adjuvant at 10 UG/vaccine
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